Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.44 |
| ▸ | CDK9 | P50750 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | QDPR | P09417 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5817065 | 0.93 | ABCB1 (0.47) | GRM5GRM1PDK4NAMPTABCB1 | |
| SCHEMBL5821778 | 0.91 | KDM4E (0.46) | GRM5GRM1PDK4NAMPTABCB1 | |
| SCHEMBL5822413 | 0.88 | ABCB1 (0.52) | ABCB1CCNT1CDK9KDM4EMEN1 | |
| SCHEMBL5821596 | 0.83 | GRM5 (0.51) | GRM5GRM1PDK4NAMPTCNR1 | |
| SCHEMBL5821389 | 0.82 | KDM4E (0.43) | GRM5GRM1ABCB1CCNT1CDK9 | |
| SCHEMBL29580432 | 0.81 | PDK4 (0.67) | GRM5GRM1PDK4NAMPTCNR1 | |
| SCHEMBL4859866 | 0.81 | PDK4 (0.67) | GRM5GRM1PDK4NAMPTCNR1 | |
| SCHEMBL5821626 | 0.81 | CCNT1 (0.42) | ABCB1CCNT1CDK9KDM4EMEN1 | |
| SCHEMBL5824103 | 0.80 | ABCB1 (0.41) | GRM5GRM1ABCB1KDM4EMEN1 | |
| SCHEMBL5816276 | 0.80 | KDM4E (0.50) | ABCB1CCNT1CDK9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235037-A1 | Heterocyclic inhibitors of protein arginine methyl transferases | BRISTOL-MYERS SQUIBB COMPANY | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235037-A1 | Heterocyclic inhibitors of protein arginine methyl transferases | PRMT1, PRMT3, PRMT8 | GRM5 4231/4885GRM1 3388/4885PDK4 2813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.