Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | MMP1 | P03956 | 4/20 | 0.57 |
| ▸ | MMP2 | P08253 | 4/20 | 0.57 |
| ▸ | MMP9 | P14780 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5952682 | 1.00 | MEN1 (0.65) | MEN1KMT2ACYP1A2NPSR1MMP1 | |
| SCHEMBL14135715 | 1.00 | MEN1 (0.65) | MEN1KMT2ACYP1A2NPSR1MMP1 | |
| SCHEMBL23367403 | 0.84 | MEN1 (0.49) | MEN1KMT2ACYP1A2NPSR1MMP1 | |
| SCHEMBL1398153 | 0.82 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1TP53 | |
| SCHEMBL9289784 | 0.82 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1TP53 | |
| SCHEMBL1398151 | 0.82 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1TP53 | |
| SCHEMBL4997889 | 0.80 | CYP1A2 (0.64) | MEN1KMT2ACYP1A2NPSR1MMP1 | |
| SCHEMBL7368786 | 0.80 | CYP1A2 (0.64) | MEN1KMT2ACYP1A2NPSR1TP53 | |
| SCHEMBL4997896 | 0.80 | CYP1A2 (0.64) | MEN1KMT2ACYP1A2NPSR1MMP1 | |
| SCHEMBL8572562 | 0.80 | CYP1A2 (0.64) | MEN1KMT2ACYP1A2NPSR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | disclosed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | CDK9, BMX, SBK3 | MEN1 2639/4885KMT2A 1678/4885CYP1A2 354/4885 |
| US-20040048868-A1 | Benzimidazoles | CDK9, BMX, CDKN1A | MEN1 1460/4885KMT2A 1844/4885CYP1A2 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.