Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951415 | 0.83 | CYBB (0.36) | METAP1ACHE | |
| SCHEMBL5951765 | 0.83 | HTR2A (0.40) | HTR2AHTR2CHTR2BMETAP1NOS3 | |
| SCHEMBL5952581 | 0.80 | GRM2 (0.41) | HTR2AHTR2CHTR2BMETAP1NOS3 | |
| SCHEMBL2388260 | 0.79 | HTR2A (0.37) | HTR2AHTR2CHTR2BMETAP1NOS3 | |
| SCHEMBL5951450 | 0.78 | METAP1 (0.41) | METAP1OXTRACHE | |
| SCHEMBL5952451 | 0.78 | ACHE (0.39) | HTR2AHTR2CHTR2BMETAP1NOS3 | |
| SCHEMBL5952510 | 0.77 | NOS3 (0.38) | HTR2AHTR2CHTR2BMETAP1NOS3 | |
| SCHEMBL5952062 | 0.77 | HTR2C (0.36) | HTR2AHTR2CHTR2BNOS3 | |
| SCHEMBL4480887 | 0.76 | HTR2A (0.43) | HTR2AHTR2CHTR2BNOS3ABCB1 | |
| SCHEMBL5951525 | 0.76 | METAP1 (0.40) | METAP1ABCB1AADATACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7038070-B2 | Preparation of preparing substituted indanones | BASELL POLYOLEFINE GMBH (DE) | 2006-05-02 | — | — | US | disclosed |
| US-6963017-B2 | Preparation of preparing substituted indanones | BASELL POLYOLEFINE GMBH (DE) | 2005-11-08 | — | — | US | disclosed |
| EP-0968158-B1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | BASELL POLYOLEFINE GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| US-20050033076-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2005-02-10 | — | — | US | disclosed |
| US-20030009046-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033076-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP2J2, IDH3A | HTR2A 2569/4885HTR2C 2534/4885HTR2B 3049/4885 |
| US-20030009046-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP1B1, CYP1A1 | HTR2A 2727/4885HTR2C 2626/4885HTR2B 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.