Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.95 |
| ▸ | HPGD | P15428 | 6/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.95 |
| ▸ | CA12 | O43570 | 2/20 | 0.95 |
| ▸ | CA1 | P00915 | 2/20 | 0.95 |
| ▸ | CA2 | P00918 | 2/20 | 0.95 |
| ▸ | CA7 | P43166 | 2/20 | 0.95 |
| ▸ | CA9 | Q16790 | 2/20 | 0.95 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.95 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.95 |
| ▸ | CA4 | P22748 | 1/20 | 0.95 |
| ▸ | CA6 | P23280 | 1/20 | 0.95 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.95 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | G6PD | P11413 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL29386727 | 1.00 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL9947692 | 0.97 | ALDH1A1 (0.90) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29360246 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL17156443 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1967 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29362663 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29606432 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1509155 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8433746 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL546853 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060153935-A1 | Stabilizing salicylate compositions and method of preparation for oral and topical use | BLAHUT NATALIE | 2006-07-13 | — | — | US | claimed |
| US-RE38576-E1 | Stabilized aspirin compositions and method of preparation for oral and topical use | BLAHUT NATALIE | 2004-08-31 | — | — | US | claimed |
| US-RE38443-E1 | Stabilized aspirin compositions and method of preparation of oral and topical use | BLAHUT NATALIE | 2004-02-24 | — | — | US | claimed |
| US-6248731-B1 | FORMATION OF POTASSIUM SALICYLIC ACID OR POTASSIUM ACETYLSALICYLIC ACID SALT BY REACTION WITH POTASSIUM HYDROXIDE IN AN AQUEOUS SOLUTION, THEN DEHYDRATING SALT | BLAHUT NATALIE (US) | 2001-06-19 | — | — | US | claimed |
| US-6177413-B1 | DISSOLVING SALICYLIC ACID AND ACETYLSALICYLIC ACID IN AQUEOUS POTASSIUM HYDROXIDE, DRYING, MIXING THE SALT WITH A LIQUID CARRIER | BLAHUT NATALIE (US) | 2001-01-23 | — | — | US | claimed |
| EP-2061309-B1 | COMPOSITIONS AND METHODS OF USE THEREOF FOR THE REMOVAL OF TICKS FROM EPIDERMAL TISSUE | KARYKION INC (US) | 2015-10-28 | — | — | EP | disclosed |
| US-20060153935-A1 | Stabilizing salicylate compositions and method of preparation for oral and topical use | BLAHUT NATALIE | 2006-07-13 | — | — | US | disclosed |
| US-20060153935-A1 | Stabilizing salicylate compositions and method of preparation for oral and topical use | BLAHUT NATALIE | 2006-07-13 | — | — | US | disclosed |
| EP-1484643-A1 | Method for preparing bleach-fixing processing solution for silver halide color photographic light sensitive material, starter for concentrated bleach-fixing composition and method for processing of photographic light-sensitive material | Konica Minolta Photo Imaging, Inc. (JP) | 2004-12-08 | — | — | EP | disclosed |
| US-20040241597-A1 | Method for preparing bleach-fixing processing solution for silver halide color photographic light sensitive material, starter for concentrated bleach-fixing composition and method for processing of photographic light sensitive material | KONICA MINOLTA PHOTO IMAGING, INC. (JP) | 2004-12-02 | — | — | US | disclosed |
| US-RE38576-E1 | Stabilized aspirin compositions and method of preparation for oral and topical use | BLAHUT NATALIE | 2004-08-31 | — | — | US | disclosed |
| US-RE38443-E1 | Stabilized aspirin compositions and method of preparation of oral and topical use | BLAHUT NATALIE | 2004-02-24 | — | — | US | disclosed |
| US-6248731-B1 | FORMATION OF POTASSIUM SALICYLIC ACID OR POTASSIUM ACETYLSALICYLIC ACID SALT BY REACTION WITH POTASSIUM HYDROXIDE IN AN AQUEOUS SOLUTION, THEN DEHYDRATING SALT | BLAHUT NATALIE (US) | 2001-06-19 | — | — | US | disclosed |
| US-6177413-B1 | DISSOLVING SALICYLIC ACID AND ACETYLSALICYLIC ACID IN AQUEOUS POTASSIUM HYDROXIDE, DRYING, MIXING THE SALT WITH A LIQUID CARRIER | BLAHUT NATALIE (US) | 2001-01-23 | — | — | US | disclosed |
| EP-0452886-A2 | Method of processing a silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |