Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4616899 | 1.00 | CYP3A4 (0.48) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| SCHEMBL4399111 | 1.00 | CYP3A4 (0.48) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| SCHEMBL4399114 | 1.00 | CYP3A4 (0.48) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| Hydrochloric Acid SCHEMBL5549564 | 0.99 | ACE (0.49) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| Hydrochloric Acid SCHEMBL4614963 | 0.99 | ACE (0.49) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| Hydrochloric Acid SCHEMBL5593751 | 0.99 | ACE (0.49) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| Hydrochloric Acid SCHEMBL5791761 | 0.99 | ACE (0.49) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| Hydrochloric Acid SCHEMBL4616123 | 0.99 | ACE (0.49) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| Hydrochloric Acid SCHEMBL5793334 | 0.99 | ACE (0.49) | CYP3A4KMT2AALDH1A1KDM4EACE | |
| SCHEMBL646159 | 0.97 | CYP3A4 (0.48) | CYP3A4KMT2AALDH1A1KDM4EACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060079698-A1 | Process for the preparation of intermediates of trandolapril and use thereof for the preparation of trandolapril | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079698-A1 | Process for the preparation of intermediates of trandolapril and use thereof for the preparation of trandolapril | TFPI2, TFPI, TPH2 | CYP3A4 41/4885KMT2A 1474/4885ALDH1A1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.