Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.47 |
| ▸ | ACVR1B | P36896 | 7/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.47 |
| ▸ | BUB1 | O43683 | 2/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954799 | 0.90 | TGFBR1 (0.57) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL8347154 | 0.88 | TGFBR1 (0.70) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL8347945 | 0.88 | BUB1 (0.58) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL2212684 | 0.84 | TGFBR1 (0.64) | TGFBR1MAPK9MAPK10ACVRL1ACVR1B | |
| SCHEMBL8347944 | 0.83 | TGFBR1 (0.50) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL2491506 | 0.83 | TGFBR1 (0.54) | TGFBR1MAPK9MAPK10ACVRL1ACVR1B | |
| SCHEMBL5955198 | 0.81 | TGFBR1 (0.48) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL12426164 | 0.81 | TGFBR1 (0.51) | TGFBR1MAPK9MAPK10ACVRL1ACVR1B | |
| SCHEMBL2202148 | 0.80 | TGFBR1 (0.51) | TGFBR1MAPK9MAPK10ACVRL1ACVR1B | |
| SCHEMBL12426213 | 0.80 | TGFBR1 (0.52) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060281763-A1 | Carboxamide inhibitors of TGFbeta | SCIOS INC. | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281763-A1 | Carboxamide inhibitors of TGFbeta | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885MAPK9 1011/4885MAPK10 1059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.