Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | METAP2 | P50579 | 3/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.60 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.60 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.54 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.54 |
| ▸ | CKS1B | P61024 | 1/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512984 | 0.94 | CYP2C9 (0.90) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL14075396 | 0.94 | CYP2C9 (0.73) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL12200967 | 0.93 | CYP2C9 (0.76) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL3514014 | 0.91 | CYP2C9 (0.77) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL13034761 | 0.91 | CYP2C9 (0.84) | CYP2C9CYP1A2CYP2C19METAP2GFER | |
| SCHEMBL5955266 | 0.91 | CYP2C9 (0.69) | CYP2C9CYP1A2CYP2C19KEAP1NFE2L2 | |
| SCHEMBL7322109 | 0.90 | METAP2 (0.73) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL5956141 | 0.89 | CYP2C9 (0.68) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL3513665 | 0.89 | CYP2C9 (0.82) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 | |
| SCHEMBL3513101 | 0.87 | CYP2C9 (0.79) | CYP2C9CYP1A2CYP2C19METAP2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014405-A2 | SULFONAMIDE-BASED COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-02-09 | — | — | WO | claimed |
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | claimed |
| WO-2006014405-A2 | SULFONAMIDE-BASED COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | SRC, LCK, ABL1 | CYP2C9 4172/4885CYP1A2 4248/4885CYP2C19 3983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.