Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.73 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12200967 | 0.92 | CYP2C9 (0.76) | METAP2FFAR4CYP2C9CYP1A2KEAP1 | |
| SCHEMBL5955445 | 0.90 | CYP2C9 (0.84) | METAP2FFAR4CYP2C9CYP1A2KEAP1 | |
| SCHEMBL7316092 | 0.90 | CYP2C9 (0.68) | METAP2FFAR4CYP2C9CYP1A2KEAP1 | |
| SCHEMBL12570805 | 0.89 | METAP2 (0.86) | METAP2CYP2C9CYP1A2POLBCYP2C19 | |
| SCHEMBL14075396 | 0.88 | CYP2C9 (0.73) | METAP2FFAR4CYP2C9CYP1A2KEAP1 | |
| SCHEMBL16479406 | 0.87 | LMNA (0.68) | METAP2FFAR4CYP2C9CYP1A2KEAP1 | |
| SCHEMBL10249221 | 0.86 | ACLY (0.67) | METAP2KEAP1NFE2L2ALDH1A1LMNA | |
| SCHEMBL3512984 | 0.85 | CYP2C9 (0.90) | METAP2FFAR4CYP2C9CYP1A2KEAP1 | |
| SCHEMBL2009251 | 0.85 | METAP2 (1.00) | METAP2CYP2C9CYP1A2ALDH1A1LMNA | |
| SCHEMBL23200290 | 0.84 | CYP2C9 (0.76) | METAP2FFAR4CYP2C9CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | UNIVERISTY OF SOUTH CAROLINA | 2024-01-25 | — | — | US | disclosed |
| US-20200399297-A1 | Small Molecule Inhibitors Selective for Polo-Like Kinase Proteins | UNIVERSITY OF SOUTH CAROLINA | 2020-12-24 | — | — | US | disclosed |
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | PLK2, PLK4, PLK3 | METAP2 3732/4885FFAR4 3848/4885CYP2C9 4652/4885 |
| US-20200399297-A1 | Small Molecule Inhibitors Selective for Polo-Like Kinase Proteins | PLK2, PLK4, PLK3 | METAP2 3688/4885FFAR4 3955/4885CYP2C9 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.