Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956969 | 0.80 | F10 (0.65) | F10KLKB1CFD | |
| SCHEMBL5956980 | 0.78 | F10 (0.51) | F10KLKB1CFDCYP2C9CYP2C19 | |
| SCHEMBL5956914 | 0.78 | F10 (0.52) | F10KLKB1MEN1KMT2ACFD | |
| SCHEMBL5957003 | 0.78 | F10 (0.48) | F10POLBKLKB1KMT2ACFD | |
| SCHEMBL5956946 | 0.77 | F10 (0.67) | F10POLB | |
| SCHEMBL28189020 | 0.76 | POLB (0.54) | F10POLBKLKB1MEN1KMT2A | |
| SCHEMBL12101335 | 0.75 | F10 (0.41) | F10KLKB1CFDCYP2C9CYP2C19 | |
| SCHEMBL8230607 | 0.75 | F10 (0.41) | F10KLKB1CFDCYP2C9CYP2C19 | |
| SCHEMBL12101339 | 0.75 | F10 (0.41) | F10POLBKLKB1MEN1KMT2A | |
| SCHEMBL3591919 | 0.74 | POLB (0.43) | F10POLBKLKB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633346-B1 | PYRROLIDIN-1, 2- DICARBOXYLIC ACID- 1- (4- ETHINYL- PHENYL) - AMID|- 2- (PHENYL)- AMID| DERIVATIVE AS INHIBITORS OF COAGULATION FACTOR XA AND VIIA FOR THE TREATMENT OF THROMBOSIS | MERCK PATENT GMBH (DE) | 2006-08-23 | — | — | EP | claimed |