Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 7/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 5/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 5/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyroxamide SCHEMBL154681 | 1.00 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| Pyroxamide SCHEMBL30184775 | 1.00 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL15480449 | 0.94 | HDAC3 (0.88) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL8277953 | 0.88 | HDAC3 (0.78) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL13477810 | 0.88 | LMNA (0.81) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL823590 | 0.87 | HDAC3 (0.76) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL16596336 | 0.87 | LMNA (1.00) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL823570 | 0.87 | LMNA (1.00) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL30444393 | 0.87 | LMNA (1.00) | HDAC1HDAC8HDAC2HDAC11HDAC6 | |
| SCHEMBL14415898 | 0.87 | LMNA (1.00) | HDAC1HDAC8HDAC2HDAC11HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060148804-A1 | Pde4 inhibitors for the treatment of neoplasms of lymphoid cells | NYCOMED GMBH (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1587512-A2 | PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS | ALTANA Pharma AG (DE) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004062671-A2 | PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS | ALTANA PHARMA AG (DE) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148804-A1 | Pde4 inhibitors for the treatment of neoplasms of lymphoid cells | PDE4A, PDE4B, PDE4C | HDAC1 1221/4885HDAC8 1063/4885HDAC2 1480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.