Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.76 |
| ▸ | FAAH | O00519 | 1/20 | 0.74 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28315011 | 1.00 | LMNA (1.00) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL823570 | 1.00 | LMNA (1.00) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL14415898 | 1.00 | LMNA (1.00) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL30444393 | 1.00 | LMNA (1.00) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL27813733 | 0.98 | LMNA (0.97) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL10788231 | 0.94 | LMNA (0.89) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL15480449 | 0.92 | HDAC3 (0.88) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL18255374 | 0.92 | FAAH (0.88) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL18328432 | 0.90 | LMNA (0.82) | LMNAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL13477810 | 0.90 | LMNA (0.81) | LMNAPOLBHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751851-B2 | Molecules and compositions that inhibit gram negative bacteria and their uses | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2017-09-05 | — | — | US | disclosed |
| US-9751851-B2 | Molecules and compositions that inhibit gram negative bacteria and their uses | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160368892-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160368892-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-12-22 | — | — | US | disclosed |
| WO-2015042363-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368892-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | BLVRB, PGLS, GRHPR | LMNA 4678/4885POLB 1770/4885HDAC3 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.