Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035136 | 0.91 | DRD2 (0.37) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL3039847 | 0.91 | DRD2 (0.37) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL5954233 | 0.91 | DRD2 (0.37) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6627467 | 0.81 | LMNA (0.40) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6627473 | 0.81 | LMNA (0.40) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6630201 | 0.81 | LMNA (0.40) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6626563 | 0.81 | LMNA (0.40) | TSHRLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL7395323 | 0.79 | DRD2 (0.45) | LMNAMAPTDRD2ADRA1DSLC6A4 | |
| SCHEMBL7397482 | 0.79 | DRD2 (0.44) | TSHRLMNAALDH1A1DRD2SLC6A4 | |
| SCHEMBL7395078 | 0.79 | DRD2 (0.41) | LMNAALDH1A1MAPK1DRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| US-5962465-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |
| US-5756532-A | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |