Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30887165 | 1.00 | DRD2 (0.46) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL10233648 | 0.92 | DRD2 (0.44) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL9637836 | 0.89 | KDM4E (0.51) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL9847654 | 0.87 | DRD2 (0.47) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL11183111 | 0.86 | DRD2 (0.46) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL27501851 | 0.85 | DRD2 (0.42) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL11425582 | 0.85 | DRD2 (0.43) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL6141223 | 0.85 | DRD2 (0.43) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL7528964 | 0.85 | DRD2 (0.41) | DRD2DRD4KDM4ECRHBPCRHR2 | |
| SCHEMBL8942319 | 0.84 | DRD2 (0.46) | DRD2DRD4KDM4ECRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102797043-B | Medicinal molecular fragment library and construction process thereof | Tianli (Tianjin) Technology Co., Ltd. (CN) | 2015-11-25 | — | — | CN | claimed |
| EP-0545415-B1 | Process for the preparation of arylidene dyes | EASTMAN KODAK CO (US) | 1997-06-18 | — | — | EP | claimed |
| EP-0545415-A2 | Process for the preparation of arylidene dyes | EASTMAN KODAK COMPANY (US) | 1993-06-09 | — | — | EP | claimed |
| US-5214186-A | Reaction of alkyl formate, methylene compound, and aromatic amine | EASTMAN KODAK COMPANY (US) | 1993-05-25 | — | — | US | claimed |
| CN-1040998-A | HETEROCYCLIC ACTIVE DISPERSE DYE | DALIAN SCIENCE AND TECHNOLOGY (CN) | 1990-04-04 | — | — | CN | claimed |
| CN-109053712-A | A kind of 2- aminothiophene -3- carboxylate methyl ester derivative C15H22N2O5The synthetic method of S | 南京大学连云港高新技术研究院 | 2018-12-21 | — | — | CN | disclosed |
| CN-102797043-B | Medicinal molecular fragment library and construction process thereof | Tianli (Tianjin) Technology Co., Ltd. (CN) | 2015-11-25 | — | — | CN | disclosed |
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| EP-2376085-B1 | COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-02-26 | — | — | EP | disclosed |
| US-20140005190-A1 | COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2012-07-19 | — | — | US | disclosed |
| EP-0017558-A1 | Heterocyclic azo compounds having sulfate groups | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4185151-A | 1-R-2-(U-HYDROXYALKYL-2,2,4-TRIMETHYL TETRAHYDROQUINOL-6-YL) BENZ(CD)INDOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | disclosed |
| US-4088673-A | Process for the preparation of styryl dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1978-05-09 | — | — | US | disclosed |
| US-4077962-A | WATER INSOLUBLE, GREEN-YELLOW, SYNTHETIC FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-07 | — | — | US | disclosed |
| US-4012372-A | MONOAZO DISPERSE DYES | EASTMAN KODAK COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-4000141-A | SUBSTITUTED TETRAHYDRO QUINOLINE CATIONIC DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
| US-3991042-A | Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-09 | — | — | US | disclosed |
| US-3951942-A | Phenyl-azo-tetrahydroquinoline azo compounds | THE UNIVERSITY OF DELAWARE (US) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005190-A1 | COMPOUNDS AND METHODS OF USE | BCL2A1, BCL2, BAX | DRD2 3380/4885DRD4 2844/4885KDM4E 2909/4885 |
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | BCL2A1, BCL2, BAX | DRD2 3380/4885DRD4 2844/4885KDM4E 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.