Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210291 | 0.77 | HSD17B10 (0.50) | SMN1; SMN2HSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL16437815 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2HSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL4528112 | 0.74 | HSD17B10 (0.37) | SMN1; SMN2HSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL8616898 | 0.71 | DDR1 (0.40) | SMN1; SMN2HSD17B10GAAMAPTKDM4E | |
| SCHEMBL19628643 | 0.71 | PIK3CG (0.35) | SMN1; SMN2HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL4528040 | 0.69 | ALDH1A1 (0.41) | SMN1; SMN2HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL5486555 | 0.67 | HTT (0.38) | SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL16440380 | 0.66 | CYP1A2 (0.40) | SMN1; SMN2HSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL20646882 | 0.66 | GAA (0.69) | SMN1; SMN2HSD17B10ALDH1A1TSHRGAA | |
| SCHEMBL8829476 | 0.65 | HSD17B10 (0.43) | SMN1; SMN2HSD17B10ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709019-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068444-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-07-28 | — | — | WO | disclosed |