SCHEMBL5960508

SCHEMBL5960508

Cc1ccc(S(=O)(=O)c2[nH]c3ccccc3c2I)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.56
SRC P12931 1/20 0.56
PTGS2 P35354 5/20 0.51
ALDH1A1 P00352 1/20 0.48
IDO1 P14902 1/20 0.48
TDO2 P48775 1/20 0.48
CNR1 P21554 1/20 0.46
GAA P10253 1/20 0.44
BCHE P06276 1/20 0.42
ACHE P22303 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
KIF11 P52732 1/20 0.40
CTSV O60911 1/20 0.40
CTSL P07711 1/20 0.40
HPGD P15428 1/20 0.40
NPC1 O15118 2/20 0.40
KEAP1 Q14145 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7835359 0.87 HTR6 (0.43) EGFRSRCPTGS2ALDH1A1IDO1
SCHEMBL4189420 0.82 EGFR (0.56) EGFRSRCPTGS2ALDH1A1IDO1
SCHEMBL6166809 0.81 EGFR (0.55) EGFRSRCPTGS2ALDH1A1IDO1
SCHEMBL9051693 0.81 EGFR (0.66) EGFRSRCPTGS2ALDH1A1IDO1
SCHEMBL7515319 0.78 EGFR (0.52) EGFRSRCPTGS2ALDH1A1IDO1
SCHEMBL29414726 0.77 EGFR (0.51) EGFRSRCPTGS2ALDH1A1IDO1
SCHEMBL4044510 0.77 MAPT (0.46) PTGS2ALDH1A1GAABCHEACHE
SCHEMBL12615337 0.77 BCHE (0.46) EGFRSRCALDH1A1GAABCHE
SCHEMBL18160178 0.76 EGFR (0.68) EGFRSRCPTGS2ALDH1A1GAA
SCHEMBL29988920 0.75 EGFR (0.66) EGFRSRCPTGS2ALDH1A1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893576-A1 TREATMENT OF PROTEIN FOLDING DISORDERS QUEEN'S UNIVERSITY AT KINGSTON (CA) 2008-03-05 EP disclosed
WO-2006125324-A1 TREATMENT OF PROTEIN FOLDING DISORDERS QUEEN'S UNIVERSITY AT KINGSTON (CA) 2006-11-30 WO disclosed