Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azilect. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 8/20 | 0.75 |
| ▸ | ACHE | P22303 | 12/20 | 0.75 |
| ▸ | MAOA | P21397 | 7/20 | 0.75 |
| ▸ | BCHE | P06276 | 2/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | HTR6 | P50406 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rasagiline SCHEMBL8488531 | 1.00 | ACHE (0.75) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL241721 | 1.00 | ACHE (0.75) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL7196981 | 1.00 | ACHE (0.75) | ACHEMAOBMAOABCHEADRA2B | |
| Azilect SCHEMBL2342865 | 1.00 | ACHE (0.75) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL2031233 | 1.00 | ACHE (0.75) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL7337913 | 1.00 | ACHE (0.75) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL932650 | 0.90 | ACHE (0.83) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL1972002 | 0.90 | ACHE (0.83) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL828682 | 0.90 | ACHE (0.83) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL2173398 | 0.89 | ACHE (0.70) | ACHEMAOBMAOABCHEADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929298-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(-)-N-PROPARGYL-1-AMINO INDAN | TEVA PHARMA (IL) | 2006-06-07 | — | — | EP | disclosed |
| US-6277886-B1 | ADMINISTERING TO TREAT SUBJECT SUFFERING FROM NEUROTRAUMA | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2001-08-21 | — | — | US | disclosed |
| EP-0929298-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(-)-N-PROPARGYL-1-AMINO INDAN | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998002152-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(-)-N-PROPARGYL-1-AMINO INDAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1998-01-22 | — | — | WO | disclosed |