Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 10/20 | 0.59 |
| ▸ | AKR1C1 | Q04828 | 10/20 | 0.59 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23823369 | 0.83 | AKR1C2 (0.53) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL2149302 | 0.82 | AKR1C2 (0.52) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL691741 | 0.82 | AKR1C2 (0.52) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL28030639 | 0.80 | DPP4 (0.53) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL27887946 | 0.80 | TPMT (0.47) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL11225434 | 0.79 | AKR1C2 (0.64) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL18677518 | 0.79 | AKR1C2 (0.53) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL1513825 | 0.78 | AKR1C2 (0.63) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL4126506 | 0.78 | HMGB1 (0.57) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 | |
| SCHEMBL5318766 | 0.77 | AKR1C2 (0.61) | AKR1C2AKR1C1AKR1C4AKR1C3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889552-B2 | Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof | ONCOZEN CO.. LTD. (KR) | 2021-01-12 | — | — | US | disclosed |
| US-10464907-B2 | Compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof | INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY (KR) | 2019-11-05 | — | — | US | disclosed |
| US-20190031620-A1 | NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF | INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY (KR) | 2019-01-31 | — | — | US | disclosed |
| WO-2017051020-A1 | DYE COMPOSITION COMPRISING A RESORCINOL-BASED COUPLER AND AN OXIDATION BASE | L'OREAL (FR) | 2017-03-30 | — | — | WO | disclosed |
| US-RE39088-E1 | Amide compounds and use of the same | JAPAN TOBACCO, INC. (JP) | 2006-05-02 | — | — | US | disclosed |
| EP-0849256-B1 | AMIDE COMPOUNDS AND USE OF THE SAME | JAPAN TOBACCO INC (JP) | 2005-06-08 | — | — | EP | disclosed |
| EP-1304322-A2 | Carboxylic acid compound and use thereof | Japan Tobacco Inc. (JP) | 2003-04-23 | — | — | EP | disclosed |
| US-6420561-B1 | Amide compounds and use thereof | JAPAN TOBACCO INC. (JP) | 2002-07-16 | — | — | US | disclosed |
| US-6174887-B1 | Amide compounds and use of the same | JAPAN TOBACCO INC. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0849256-A1 | AMIDE COMPOUNDS AND USE OF THE SAME | Japan Tobacco Inc. (JP) | 1998-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889552-B2 | Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof | HSP90AB1, HSP90AA1, HSP90AB2P | AKR1C2 3577/4885AKR1C1 3767/4885AKR1C4 3922/4885 |
| US-20190031620-A1 | NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF | HSP90AA1, HSP90AB1, HSP90AB2P | AKR1C2 3881/4885AKR1C1 3988/4885AKR1C4 4111/4885 |
| US-10464907-B2 | Compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof | HSP90AA1, HSP90AB1, HSP90AB2P | AKR1C2 4026/4885AKR1C1 4110/4885AKR1C4 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.