Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9997946 | 0.96 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10BACE1FAAH | |
| SCHEMBL9997945 | 0.96 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10BACE1FAAH | |
| SCHEMBL9998136 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LMNAHSD17B10FAAHALOX15 | |
| SCHEMBL9998134 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LMNAHSD17B10FAAHALOX15 | |
| SCHEMBL9997348 | 0.84 | FAAH (0.45) | ALDH1A1LMNAHSD17B10FAAHPTPN1 | |
| SCHEMBL9997346 | 0.84 | FAAH (0.45) | ALDH1A1LMNAHSD17B10FAAHPTPN1 | |
| SCHEMBL9998377 | 0.83 | ALDH1A1 (0.38) | ALDH1A1LMNAHSD17B10BACE1FAAH | |
| SCHEMBL9998381 | 0.83 | ALDH1A1 (0.38) | ALDH1A1LMNAHSD17B10BACE1FAAH | |
| SCHEMBL9998204 | 0.82 | FAAH (0.47) | ALDH1A1LMNAHSD17B10FAAHALOX15 | |
| SCHEMBL9997814 | 0.82 | FAAH (0.47) | ALDH1A1LMNAHSD17B10FAAHALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624881-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING INSECTS | VANDERBILT UNIVERSITY (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004100971-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING INSECTS | VANDERBILT UNIVERSITY (US) | 2004-11-25 | — | — | WO | disclosed |