Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27599863 | 0.82 | EPHX2 (0.75) | EPHX2MAPTHTTALDH1A1HPGD | |
| SCHEMBL4110392 | 0.81 | MAPT (0.64) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL29556410 | 0.81 | MTOR (0.61) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL27599887 | 0.81 | TP53 (0.68) | MAPTHTTALDH1A1GAAALOX15 | |
| SCHEMBL2095973 | 0.80 | ALDH1A1 (0.60) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL2095975 | 0.80 | ALDH1A1 (0.60) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL12480670 | 0.80 | L3MBTL1 (0.61) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL29555946 | 0.80 | MAPT (0.61) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL11195290 | 0.80 | MAPT (0.68) | EPHX2MAPTHTTALDH1A1GAA | |
| SCHEMBL29555891 | 0.80 | P2RX1 (0.67) | EPHX2MAPTHTTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992086-B2 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| US-6670364-B2 | For example (1,3-dimethylpyrazolo(5,4-b)pyridin-5-yl)-N-(((4-fluorophenyl) amino)carbonyl)-carboxamide; useful in prevention or treatment of chronic or acute inflammatory or autoimmune diseases | TELIK, INC. | 2003-12-30 | — | — | US | disclosed |