Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 4/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11030727 | 0.75 | KDM4E (0.50) | ALDH1A1KDM4EHSD17B10NPSR1KMT2A | |
| SCHEMBL4940465 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10HTTKMT2A | |
| SCHEMBL2646567 | 0.69 | HSD17B10 (0.46) | ALDH1A1KDM4EHSD17B10METAP2KMT2A | |
| SCHEMBL4953550 | 0.69 | ALDH1A1 (0.45) | ALDH1A1KDM4ELMNAKMT2AMAPT | |
| SCHEMBL4455438 | 0.66 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL30772981 | 0.66 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL11082114 | 0.66 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10LMNAHTT | |
| SCHEMBL28080648 | 0.65 | HPGD (0.47) | ALDH1A1KDM4EHSD17B10LMNANPSR1 | |
| SCHEMBL31260433 | 0.65 | ALDH1A1 (0.47) | ALDH1A1KDM4EHTTKMT2AMEN1 | |
| SCHEMBL14051486 | 0.65 | ALDH1A1 (0.50) | ALDH1A1KMT2AMAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | Morand, Eric | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | MIF, ARG1, MSR1 | ALDH1A1 1551/4885KDM4E 3166/4885HSD17B10 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.