Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 10/20 | 0.41 |
| ▸ | HRH1 | P35367 | 10/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965633 | 0.86 | KCNH2 (0.49) | KCNH2HRH2HRH1POLBHRH3 | |
| SCHEMBL5965476 | 0.86 | KCNH2 (0.41) | KCNH2HRH2HRH1POLBMEN1 | |
| SCHEMBL5965487 | 0.85 | HRH2 (0.44) | KCNH2HRH2HRH1POLBHRH3 | |
| SCHEMBL5965389 | 0.85 | SIGMAR1 (0.45) | KCNH2HRH1HRH3MEN1SIGMAR1 | |
| SCHEMBL5965947 | 0.84 | KCNH2 (0.40) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL5965813 | 0.81 | KCNH2 (0.38) | KCNH2HRH2HRH1POLBMEN1 | |
| SCHEMBL5965436 | 0.81 | HRH3 (0.45) | HRH1HRH3MEN1 | |
| SCHEMBL5965524 | 0.81 | KCNH2 (0.39) | KCNH2HRH2HRH1POLBHRH3 | |
| SCHEMBL5965974 | 0.80 | CHRNA7 (0.39) | KCNH2HRH2HRH1POLBHRH3 | |
| SCHEMBL5965704 | 0.80 | MMP2 (0.40) | KCNH2HRH2HRH1HRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012074-B2 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-03-14 | — | — | US | disclosed |