Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 16/20 | 0.65 |
| ▸ | FLT4 | P35916 | 16/20 | 0.65 |
| ▸ | KDR | P35968 | 16/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tasisulam SCHEMBL1581371 | 0.90 | FLT1 (0.62) | FLT1FLT4KDR | |
| Tasisulam SCHEMBL29376914 | 0.90 | FLT1 (0.62) | FLT1FLT4KDR | |
| Tasisulam SCHEMBL1662355 | 0.88 | FLT1 (0.61) | FLT1FLT4KDR | |
| SCHEMBL5966441 | 0.87 | FLT1 (0.62) | FLT1FLT4KDRHTTKMT2A | |
| SCHEMBL5966461 | 0.87 | FLT1 (0.57) | FLT1FLT4KDRHTTKMT2A | |
| SCHEMBL5966465 | 0.86 | FLT1 (0.58) | FLT1FLT4KDRHTTKMT2A | |
| SCHEMBL5966555 | 0.84 | SMN1; SMN2 (0.49) | FLT1FLT4KDRHTTKMT2A | |
| SCHEMBL5514080 | 0.82 | FLT1 (0.62) | FLT1FLT4KDRTP53MAPT | |
| SCHEMBL5966464 | 0.80 | FLT1 (0.53) | FLT1FLT4KDRKMT2ATP53 | |
| SCHEMBL5959009 | 0.79 | FLT1 (1.00) | FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |