Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 14/20 | 0.57 |
| ▸ | FLT4 | P35916 | 14/20 | 0.57 |
| ▸ | KDR | P35968 | 14/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966429 | 0.87 | FLT1 (0.65) | FLT1FLT4KDRTP53MAPT | |
| Tasisulam SCHEMBL29376914 | 0.87 | FLT1 (0.62) | FLT1FLT4KDR | |
| Tasisulam SCHEMBL1581371 | 0.87 | FLT1 (0.62) | FLT1FLT4KDR | |
| Tasisulam SCHEMBL1662355 | 0.86 | FLT1 (0.61) | FLT1FLT4KDR | |
| SCHEMBL5966441 | 0.85 | FLT1 (0.62) | FLT1FLT4KDRTHRBKMT2A | |
| SCHEMBL5514080 | 0.80 | FLT1 (0.62) | FLT1FLT4KDRTP53MAPT | |
| SCHEMBL5966464 | 0.78 | FLT1 (0.53) | FLT1FLT4KDRTP53MAPT | |
| SCHEMBL31487879 | 0.77 | FLT1 (0.49) | FLT1FLT4KDRTP53MAPT | |
| SCHEMBL5966465 | 0.76 | FLT1 (0.58) | FLT1FLT4KDRTP53MAPT | |
| SCHEMBL5966466 | 0.74 | FLT1 (0.55) | FLT1FLT4KDRMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1298709-C | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2007-02-07 | — | — | CN | disclosed |
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |
| CN-1575286-A | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2005-02-02 | — | — | CN | disclosed |