Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 17/20 | 0.62 |
| ▸ | FLT4 | P35916 | 17/20 | 0.62 |
| ▸ | KDR | P35968 | 17/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966466 | 0.87 | FLT1 (0.55) | FLT1FLT4KDRPOLBTHRB | |
| SCHEMBL5966445 | 0.87 | FLT1 (0.65) | FLT1FLT4KDRALDH1A1 | |
| Tasisulam SCHEMBL29376914 | 0.87 | FLT1 (0.62) | FLT1FLT4KDR | |
| SCHEMBL5966429 | 0.87 | FLT1 (0.65) | FLT1FLT4KDRKMT2AHTT | |
| Tasisulam SCHEMBL1581371 | 0.87 | FLT1 (0.62) | FLT1FLT4KDR | |
| SCHEMBL5966459 | 0.87 | FLT1 (0.60) | FLT1FLT4KDRPOLBTHRB | |
| Tasisulam SCHEMBL1662355 | 0.86 | FLT1 (0.61) | FLT1FLT4KDR | |
| SCHEMBL5966461 | 0.85 | FLT1 (0.57) | FLT1FLT4KDRTHRBKMT2A | |
| SCHEMBL5966606 | 0.83 | FLT1 (0.60) | FLT1FLT4KDR | |
| SCHEMBL5966464 | 0.82 | FLT1 (0.53) | FLT1FLT4KDRTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1298709-C | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2007-02-07 | — | — | CN | disclosed |
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |
| CN-1575286-A | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2005-02-02 | — | — | CN | disclosed |