Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 8/20 | 0.50 |
| ▸ | FLT4 | P35916 | 8/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966458 | 0.80 | FLT1 (0.61) | FLT1FLT4KDRGPR27TRPV1 | |
| SCHEMBL5966646 | 0.78 | FLT1 (0.55) | FLT1FLT4KDR | |
| SCHEMBL5966431 | 0.76 | FLT1 (0.66) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966496 | 0.74 | FLT1 (0.50) | FLT1FLT4KDRGPR27SORT1 | |
| SCHEMBL5966447 | 0.74 | FLT1 (0.54) | FLT1FLT4KDRGPR27TRPV1 | |
| SCHEMBL5966437 | 0.74 | FLT1 (0.54) | FLT1FLT4KDRGPR27NPC1 | |
| SCHEMBL5958964 | 0.74 | FLT1 (0.54) | FLT1FLT4KDRGPR27TRPV1 | |
| SCHEMBL5959014 | 0.72 | FLT1 (0.64) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5959098 | 0.71 | FLT1 (0.80) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5958972 | 0.71 | FLT1 (0.76) | FLT1FLT4KDRGPR27EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |