Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | USP8 | P40818 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966432 | 0.89 | FLT1 (0.58) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966434 | 0.75 | FLT1 (0.55) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966492 | 0.75 | FLT1 (0.55) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966450 | 0.74 | FLT1 (0.50) | FLT1FLT4KDRGPR27CA2 | |
| SCHEMBL5966646 | 0.74 | FLT1 (0.55) | FLT1FLT4KDR | |
| SCHEMBL5958978 | 0.74 | FLT1 (0.77) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5959041 | 0.74 | FLT1 (0.65) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966451 | 0.69 | FLT1 (0.65) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966494 | 0.69 | FLT1 (0.59) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL4374839 | 0.68 | FLT1 (0.64) | FLT1FLT4KDRCES2AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |