Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 17/20 | 0.61 |
| ▸ | FLT4 | P35916 | 17/20 | 0.61 |
| ▸ | KDR | P35968 | 17/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966624 | 0.88 | FLT1 (0.59) | FLT1FLT4KDR | |
| SCHEMBL5966454 | 0.86 | FLT1 (0.56) | FLT1FLT4KDRCYP11B2GPR27 | |
| SCHEMBL5966445 | 0.81 | FLT1 (0.65) | FLT1FLT4KDRGPR27 | |
| SCHEMBL31310539 | 0.81 | FLT1 (0.58) | FLT1FLT4KDR | |
| SCHEMBL5966441 | 0.79 | FLT1 (0.62) | FLT1FLT4KDR | |
| SCHEMBL5959014 | 0.78 | FLT1 (0.64) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5966606 | 0.77 | FLT1 (0.60) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966680 | 0.76 | FLT1 (0.62) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5491420 | 0.76 | FLT1 (1.00) | FLT1FLT4KDREGFR | |
| SCHEMBL5966436 | 0.76 | FLT1 (0.56) | FLT1FLT4KDRGPR27EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |