Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 16/20 | 0.65 |
| ▸ | FLT4 | P35916 | 16/20 | 0.65 |
| ▸ | KDR | P35968 | 16/20 | 0.65 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966498 | 0.90 | FLT1 (0.62) | FLT1FLT4KDRALDH1A1 | |
| SCHEMBL5966441 | 0.87 | FLT1 (0.62) | FLT1FLT4KDRALDH1A1 | |
| SCHEMBL5966505 | 0.86 | FLT1 (0.63) | FLT1FLT4KDR | |
| SCHEMBL5966606 | 0.85 | FLT1 (0.60) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5966680 | 0.84 | FLT1 (0.62) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5966613 | 0.82 | FLT1 (0.55) | FLT1FLT4KDR | |
| SCHEMBL5966463 | 0.81 | FLT1 (0.61) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5959014 | 0.81 | FLT1 (0.64) | FLT1FLT4KDRGPR27 | |
| SCHEMBL5966509 | 0.80 | FLT1 (0.49) | FLT1FLT4KDRALDH1A1 | |
| SCHEMBL5491420 | 0.79 | FLT1 (1.00) | FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1298709-C | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2007-02-07 | — | — | CN | claimed |
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | claimed |
| CN-1575286-A | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2005-02-02 | — | — | CN | claimed |
| US-20040198784-A1 | Thiophene-amd thiazolesulfonamides as antineoplastic agents | GROSSMAN CORA SUE (US) | 2004-10-07 | — | — | US | claimed |
| EP-1442030-A1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | ELI LILLY AND COMPANY (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035629-A1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | ELI LILLY AND COMPANY (US) | 2003-05-01 | — | — | WO | claimed |
| CN-1298709-C | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2007-02-07 | — | — | CN | disclosed |
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |
| CN-1575286-A | Thiophene-amd thiazolesulfonamides as antineoplastic agents | LILLY CO ELI (US) | 2005-02-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198784-A1 | Thiophene-amd thiazolesulfonamides as antineoplastic agents | ALDH1A2, MGMT, NR2E3 | FLT1 206/4885FLT4 444/4885KDR 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.