Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | FLT4 | P35916 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966459 | 0.90 | FLT1 (0.60) | FLT1FLT4KDRSMN1; SMN2MEN1 | |
| SCHEMBL5966555 | 0.90 | SMN1; SMN2 (0.49) | FLT1FLT4KDRSMN1; SMN2MEN1 | |
| SCHEMBL5966441 | 0.87 | FLT1 (0.62) | FLT1FLT4KDRMEN1KMT2A | |
| SCHEMBL5966464 | 0.87 | FLT1 (0.53) | FLT1FLT4KDRSMN1; SMN2MEN1 | |
| SCHEMBL5966498 | 0.84 | FLT1 (0.62) | FLT1FLT4KDRSMN1; SMN2MEN1 | |
| SCHEMBL5966465 | 0.78 | FLT1 (0.58) | FLT1FLT4KDRSMN1; SMN2MEN1 | |
| SCHEMBL5966509 | 0.77 | FLT1 (0.49) | FLT1FLT4KDRSMN1; SMN2MEN1 | |
| Tasisulam SCHEMBL1581371 | 0.76 | FLT1 (0.62) | FLT1FLT4KDR | |
| SCHEMBL5966429 | 0.76 | FLT1 (0.65) | FLT1FLT4KDRKMT2AMAPT | |
| SCHEMBL5514080 | 0.76 | FLT1 (0.62) | FLT1FLT4KDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |