Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699947 | 0.84 | MCL1 (0.44) | CREBBPMCL1KDM4EMAPK1 | |
| SCHEMBL15477730 | 0.83 | MCL1 (0.43) | CREBBPMCL1KDM4ENPC1 | |
| SCHEMBL7866000 | 0.77 | MEN1 (0.46) | CREBBPMCL1KDM4ENPC1RAB9A | |
| SCHEMBL4132442 | 0.77 | DDB1 (0.53) | MCL1KDM4EDDB1CRBNMAPT | |
| SCHEMBL29973239 | 0.77 | DDB1 (0.53) | MCL1KDM4EDDB1CRBNMAPT | |
| SCHEMBL24815345 | 0.77 | DDB1 (0.53) | MCL1KDM4EDDB1CRBNMAPT | |
| SCHEMBL15874850 | 0.77 | DDB1 (0.53) | MCL1KDM4EDDB1CRBNMAPT | |
| SCHEMBL2442839 | 0.76 | PTGDR2 (0.45) | CREBBPNPC1RAB9AMAPT | |
| SCHEMBL27219376 | 0.76 | TSHR (0.53) | CREBBPKDM4ECNR2MAPT | |
| SCHEMBL2446791 | 0.75 | PTGDR2 (0.47) | KDM4ENPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663993-A1 | GUANIDINE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005023781-A1 | GUANIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-03-17 | — | — | WO | disclosed |