Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294928 | 0.87 | PDE4B (0.68) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL2645169 | 0.79 | GSTP1 (0.44) | KDM4EPOLBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL13495999 | 0.76 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DGFER | |
| SCHEMBL14492203 | 0.74 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DGFER | |
| SCHEMBL7293719 | 0.72 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL426375 | 0.71 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DGFER | |
| SCHEMBL11300173 | 0.71 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DGFER | |
| SCHEMBL16501028 | 0.71 | PKM (0.48) | PDE4APDE4BPDE4CPDE4DGFER | |
| SCHEMBL5969365 | 0.70 | TSHR (0.52) | KDM4EL3MBTL1GAAALDH1A1LMNA | |
| SCHEMBL7091735 | 0.69 | SLC6A3 (0.40) | KDM4EPOLBHSD17B10GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214345-B1 | AGENTS FOR TREATING HUMAN DISEASES, ESPECIALLY FOR TREATING TUMORS SUCH AS COLONIC CANCERS AND MELANOMAS OR FOR REGENERATING TISSUE AND PROMOTING HAIR GROWTH | MAX DELBRUECK CENTRUM (DE) | 2004-12-29 | — | — | EP | claimed |
| US-7067474-B1 | Agents for treating human illnesses based on β-catenin, and the production and use thereof | MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) | 2006-06-27 | — | — | US | disclosed |
| EP-0663395-B1 | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazole derivatives, process and intermediates for their preparation and their use as cardiac rhythm reduction agent | SOLVAY PHARM GMBH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-5679699-A | ANTIISCHEMIC AGENTS, HEART RATE LOWERING AGENTS | KALI-CHEMIE PHARMA GMBH (DE) | 1997-10-21 | — | — | US | disclosed |
| US-5547967-A | HYPOTENSIVE AGENT, ANTIISCHEMIC AGENT | KALI-CHEMIE PHARMA GMBH (DE) | 1996-08-20 | — | — | US | disclosed |
| EP-0663395-A1 | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazole derivatives, process and intermediates for their preparation and their use as cardiac rhythm reduction agent | Kali-Chemie Pharma GmbH (DE) | 1995-07-19 | — | — | EP | disclosed |