Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970275 | 0.91 | SIRT5 (0.54) | HDAC4SIRT2SIRT1SIRT5HPGDS | |
| SCHEMBL5970969 | 0.89 | SIRT5 (0.53) | HDAC4SIRT2SIRT1SIRT5HDAC1 | |
| SCHEMBL5970333 | 0.87 | HDAC4 (0.45) | HDAC4MEF2DSIRT2SIRT1SIRT5 | |
| SCHEMBL5970159 | 0.83 | CPA1 (0.44) | HDAC4SIRT1SIRT5HDAC1HDAC3 | |
| SCHEMBL5970452 | 0.82 | SIRT5 (0.57) | HDAC4SIRT2SIRT1SIRT5HDAC1 | |
| SCHEMBL5970139 | 0.79 | SIRT5 (0.55) | HDAC4SIRT2SIRT1SIRT5HPGDS | |
| SCHEMBL5970983 | 0.79 | SIRT5 (0.55) | HDAC4SIRT2SIRT1SIRT5HPGDS | |
| SCHEMBL5970497 | 0.78 | SIRT5 (0.53) | HDAC4MEF2DSIRT2SIRT1SIRT5 | |
| SCHEMBL5970494 | 0.78 | SIRT5 (0.53) | HDAC4MEF2DSIRT2SIRT1SIRT5 | |
| SCHEMBL5970251 | 0.78 | SIRT5 (0.48) | HDAC4MEF2DSIRT2SIRT1SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080070-B1 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LAB (US) | 2006-11-22 | — | — | EP | claimed |