Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970141 | 0.91 | SIRT2 (0.49) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL5970996 | 0.89 | SIRT2 (0.45) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL5970777 | 0.85 | SIRT5 (0.51) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL5970274 | 0.84 | SIRT2 (0.52) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL5970296 | 0.76 | CPA1 (0.43) | SIRT5 | |
| SCHEMBL5971121 | 0.75 | KDM4E (0.42) | — | |
| SCHEMBL5970389 | 0.72 | CPA1 (0.43) | SIRT5 | |
| SCHEMBL7867833 | 0.72 | CA1 (0.42) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL5971183 | 0.72 | SIRT5 (0.56) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL6883726 | 0.72 | SIRT5 (0.56) | SIRT2SIRT1SIRT3SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080070-B1 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LAB (US) | 2006-11-22 | — | — | EP | disclosed |