Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970274 | 0.87 | SIRT2 (0.52) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL5970777 | 0.81 | SIRT5 (0.51) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL5970141 | 0.77 | SIRT2 (0.49) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL5970996 | 0.74 | SIRT2 (0.45) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL5971002 | 0.72 | SIRT2 (0.46) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL5970328 | 0.71 | ALDH1A1 (0.47) | SIRT5 | |
| SCHEMBL21310132 | 0.70 | FOLH1 (0.64) | CA1CA2SIRT2SIRT1MMP2 | |
| SCHEMBL20677210 | 0.70 | FOLH1 (0.73) | SIRT2SIRT1MMP2MMP9FOLH1 | |
| SCHEMBL7296591 | 0.70 | FOLH1 (0.73) | SIRT2SIRT1MMP2MMP9FOLH1 | |
| SCHEMBL9866193 | 0.69 | HTT (0.58) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080070-A2 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061406-A2 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 1999-12-02 | — | — | WO | claimed |