Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970251 | 0.91 | SIRT5 (0.48) | SIRT5KMT2AHSD17B10KDM4ECYP1A2 | |
| SCHEMBL5970241 | 0.91 | SIRT5 (0.48) | SIRT5KMT2AHSD17B10KDM4ECYP1A2 | |
| SCHEMBL5970315 | 0.88 | SIRT5 (0.52) | SIRT5SIRT2SIRT1SIRT3CA1 | |
| SCHEMBL5971110 | 0.81 | KLKB1 (0.42) | SIRT5SIRT2SIRT1SIRT3CA1 | |
| SCHEMBL5970300 | 0.81 | SIRT5 (0.52) | SIRT5KMT2AALDH1A1SIRT2SIRT1 | |
| SCHEMBL5970942 | 0.81 | SIRT5 (0.52) | SIRT5KMT2AALDH1A1SIRT2SIRT1 | |
| SCHEMBL5971952 | 0.80 | SIRT5 (0.55) | SIRT5SIRT2SIRT1SIRT3CA1 | |
| SCHEMBL5970494 | 0.79 | SIRT5 (0.53) | SIRT5SIRT2SIRT1SIRT3CA1 | |
| SCHEMBL5970497 | 0.79 | SIRT5 (0.53) | SIRT5SIRT2SIRT1SIRT3CA1 | |
| SCHEMBL5970252 | 0.78 | LTA4H (0.48) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080070-B1 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LAB (US) | 2006-11-22 | — | — | EP | disclosed |
| US-6849757-B2 | Antiangiogenic drug to treat cancer, arthritis and retinopathy | ABBOTT LABORATORIES (US) | 2005-02-01 | — | — | US | disclosed |
| US-6632961-B1 | Pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to | ABBOTT LABORATORIES | 2003-10-14 | — | — | US | disclosed |