Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217087 | 0.83 | LSS (0.35) | LSS | |
| SCHEMBL7218473 | 0.83 | LSS (0.41) | LSSMEN1KMT2A | |
| SCHEMBL7218464 | 0.81 | LSS (0.41) | LSSMEN1KMT2A | |
| SCHEMBL7218488 | 0.80 | GAA (0.40) | LSSMAPTGAAMEN1KMT2A | |
| SCHEMBL7217084 | 0.79 | LSS (0.36) | LSSMEN1KMT2A | |
| SCHEMBL7218501 | 0.76 | LSS (0.45) | LSSMAPTGAA | |
| SCHEMBL7218485 | 0.76 | LSS (0.36) | LSSMEN1KMT2A | |
| SCHEMBL7218354 | 0.75 | HDAC8 (0.35) | LSSALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5635991 | 0.75 | THRB (0.44) | MAPTMEN1KMT2ALMNA | |
| SCHEMBL7212168 | 0.74 | LSS (0.47) | LSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-B1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | claimed |