Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.72 |
| ▸ | SHBG | P04278 | 2/20 | 0.72 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7891346 | 1.00 | ALDH1A1 (0.72) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL13216858 | 0.91 | ALDH1A1 (0.69) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL2832494 | 0.91 | ALDH1A1 (0.69) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL20342396 | 0.89 | ALDH1A1 (0.70) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL6357336 | 0.89 | ALDH1A1 (0.70) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL7518658 | 0.87 | ALDH1A1 (0.67) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL13372738 | 0.87 | ALDH1A1 (0.67) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL8396003 | 0.85 | ALDH1A1 (0.65) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL2838231 | 0.85 | ALDH1A1 (0.68) | ALDH1A1SERPINA6SHBGSLC22A1THRB | |
| SCHEMBL11144395 | 0.85 | ALDH1A1 (0.65) | ALDH1A1SERPINA6SHBGSLC22A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237904-B1 | 14,15-BETA-METHYLENE SUBSTITUTED ANDROGENS | AKZO NOBEL NV (NL) | 2006-02-08 | — | — | EP | disclosed |
| US-6881728-B1 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens | AKZO NOBEL N.V. (NL) | 2005-04-19 | — | — | US | disclosed |
| EP-1163259-B1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL NV (NL) | 2002-11-20 | — | — | EP | disclosed |
| EP-1237904-A2 | 14,15-BETA-METHYLENE SUBSTITUTED ANDROGENS | Akzo Nobel N.V. (NL) | 2002-09-11 | — | — | EP | disclosed |
| EP-1163259-A1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | Akzo Nobel N.V. (NL) | 2001-12-19 | — | — | EP | disclosed |
| WO-2001040255-A2 | 14,15-BETA-METHYLENE SUBSTITUTED ANDROGENS | AKZO NOBEL N.V. (NL) | 2001-06-07 | — | — | WO | disclosed |
| WO-2000053619-A1 | 14.BETA., 17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL N.V. (NL) | 2000-09-14 | — | — | WO | disclosed |