⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13547964 | 0.67 | — | — | |
| SCHEMBL1257109 | 0.67 | CDK8 (0.33) | — | |
| SCHEMBL1762078 | 0.67 | — | — | |
| SCHEMBL292333 | 0.67 | — | — | |
| SCHEMBL3820811 | 0.67 | — | — | |
| Formamide SCHEMBL10967419 | 0.64 | KEAP1 (0.39) | — | |
| SCHEMBL255119 | 0.63 | — | — | |
| SCHEMBL1353764 | 0.62 | HTT (0.56) | — | |
| SCHEMBL24159152 | 0.62 | THRB (0.49) | — | |
| SCHEMBL2551980 | 0.62 | KMT2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094232-A | P-phenylenediamine color bases F having an aliphatic chain and trialkylammonium groups and use thereof for oxidation dyeing of keratin fibers | 莱雅公司 | 2020-05-01 | — | — | CN | claimed |
| JP-60215687-A | — | — | None | — | — | JP | disclosed |
| EP-4331585-A2 | INHIBITORS OF RET | Blueprint Medicines Corporation (US) | 2024-03-06 | — | — | EP | disclosed |
| EP-4292594-A2 | INHIBITORS OF RET | Blueprint Medicines Corporation (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2023240138-A1 | INDAZOLE CONTAINING MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| EP-3371171-B1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORP (US) | 2023-10-25 | — | — | EP | disclosed |
| US-20230292759-A1 | PHENYL COMPOUND AND PLANT DISEASE CONTROL METHOD | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2023-09-21 | — | — | US | disclosed |
| CN-111423416-B | Inhibitors of RET | 缆图药品公司 | 2023-05-26 | — | — | CN | disclosed |
| CN-115873000-A | Isoquinolone and quinazolinone compounds, and composition and application thereof | 中山医诺维申新药研发有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-115448922-A | Free base crystal form containing pyrazole polycyclic derivative and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-12-09 | — | — | CN | disclosed |
| EP-1928456-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | Miikana Therapeutics, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| US-7345038-B2 | Pyridyloxymethyl and benzisoxazole azabicyclic derivatives | PFIZER, INC (US) | 2008-03-18 | — | — | US | disclosed |
| CN-1993360-A | Condensed pyridines as kinase inhibitors | PALAU PHARMA SA (ES) | 2007-07-04 | — | — | CN | disclosed |
| US-20070142368-A1 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. | 2007-06-21 | — | — | US | disclosed |
| WO-2007041358-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| EP-1608648-A1 | PYRIDYLOXYMETHYL AND BENZISOXAZOLE AZABICYCLIC DERIVATIVES | Pfizer Products Inc. (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20050026922-A1 | For treating CNS or other disorders, including concurrent treatment of disorders such as schizophrenia and depression; side effect reduction; for example, (7R,9aS)-trans-7-[6-(2,6-Dimethyl-piperidin-1-ylmethyl)-pyridin-2-yloxymethyl]-2-(5-fluoro-benzo[d]isoxazol-3-yl)-octahydro-pyrido[1,2-a]pyrazine | PFIZER INC | 2005-02-03 | — | — | US | disclosed |
| WO-2004081007-A1 | PYRIDYLOXYMETHYL AND BENZISOXAZOLE AZABICYCLIC DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| JP-S60215687-A | PRODUCTION OF PYRAZOLO(1,5-B)(1,2,4)TRIAZOLE DERIVATIVE | FUJI PHOTO FILM CO LTD | 1985-10-29 | — | — | JP | disclosed |
| US-4275073-A | PENTATHIEPINOPYRAZOLES AND PYRAZOLOTRITHIOCARBONATES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-06-23 | — | — | US | disclosed |