Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6044315 | 0.86 | GLA (0.47) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| SCHEMBL1998867 | 0.83 | KEAP1 (0.71) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| SCHEMBL5910714 | 0.82 | KEAP1 (0.58) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| Ammonia Solution, Strong SCHEMBL9400430 | 0.81 | KEAP1 (0.68) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| SCHEMBL11222517 | 0.81 | KEAP1 (0.68) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| SCHEMBL11086634 | 0.79 | HRH3 (0.52) | SMN1; SMN2MAPK1ALDH1A1POLBLMNA | |
| SCHEMBL952480 | 0.78 | KEAP1 (0.54) | SMN1; SMN2KEAP1HPGDDUSP3MAPK1 | |
| SCHEMBL7239607 | 0.78 | KEAP1 (0.71) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| SCHEMBL2181005 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1HPGDDUSP3GLA | |
| SCHEMBL6946106 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1HPGDDUSP3GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-10-20 | — | — | EP | disclosed |
| WO-2012062745-A1 | ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062743-A1 | ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-05-18 | — | — | WO | disclosed |