Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792779 | 1.00 | AKR1C3 (0.56) | AKR1C3AKR1C1MCL1CYP2C9CYP3A4 | |
| SCHEMBL1081471 | 1.00 | AKR1C3 (0.56) | AKR1C3AKR1C1MCL1CYP2C9CYP3A4 | |
| SCHEMBL11594648 | 0.86 | MCL1 (0.57) | AKR1C3AKR1C1MCL1CYP2C9CYP3A4 | |
| SCHEMBL20049735 | 0.86 | MCL1 (0.57) | AKR1C3AKR1C1MCL1CYP2C9CYP3A4 | |
| SCHEMBL17397066 | 0.86 | MCL1 (0.57) | AKR1C3AKR1C1MCL1CYP2C9CYP3A4 | |
| SCHEMBL181651 | 0.86 | MCL1 (0.52) | AKR1C3AKR1C1MCL1CYP2C9CYP3A4 | |
| SCHEMBL7044923 | 0.85 | MCL1 (0.48) | AKR1C3AKR1C1MCL1FBP1ALDH1A1 | |
| SCHEMBL859579 | 0.85 | MCL1 (0.48) | AKR1C3AKR1C1MCL1FBP1ALDH1A1 | |
| SCHEMBL11729242 | 0.82 | EGFR (0.53) | AKR1C3TP53ALDH1A1HSD17B10KDM4E | |
| SCHEMBL6940611 | 0.82 | AKR1C3 (0.57) | AKR1C3AKR1C1MCL1RECQLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449544-B2 | p21 peptides | CYCLACEL LIMITED (GB) | 2008-11-11 | — | — | US | disclosed |
| US-7449544-B2 | p21 peptides | CYCLACEL LIMITED (GB) | 2008-11-11 | — | — | US | disclosed |
| EP-1656390-A2 | COMPOSITIONS OF LIPOPEPTIDE ANTIBIOTIC DERIVATIVES AND METHODS OF USE THEREOF | MIGENIX INC. (CA) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005000878-A2 | COMPOSITIONS OF LIPOPEPTIDE ANTIBIOTIC DERIVATIVES AND METHODS OF USE THEREOF | MIGENIX INC. (CA) | 2005-01-06 | — | — | WO | disclosed |