Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203029 | 0.84 | SLC6A2 (0.41) | SLC6A3SLC6A2SLC6A4DRD1LMNA | |
| SCHEMBL6648965 | 0.82 | CYP1A2 (0.38) | SLC6A3SLC6A2SLC6A4LMNAMAPT | |
| SCHEMBL5537503 | 0.69 | CYP19A1 (0.36) | LMNAMAPTTDP1HTR2AHTR2C | |
| SCHEMBL14544198 | 0.68 | RAB9A (0.50) | SLC6A3SLC6A2SLC6A4MAPTHTR2A | |
| SCHEMBL3153900 | 0.68 | ALDH1A1 (0.37) | LMNAMAPTTDP1 | |
| SCHEMBL5981666 | 0.67 | ALDH1A1 (0.35) | LMNAMAPTTDP1L3MBTL1 | |
| SCHEMBL7794528 | 0.67 | ALDH1A1 (0.40) | LMNAMAPT | |
| SCHEMBL15492553 | 0.66 | SLC6A2 (0.44) | SLC6A3SLC6A2SLC6A4TDP1 | |
| SCHEMBL23469162 | 0.66 | SLC6A2 (0.55) | SLC6A3SLC6A2SLC6A4DRD1 | |
| SCHEMBL4972612 | 0.66 | KDM1A (0.32) | MAPTNPSR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | disclosed |