Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234394 | 0.87 | POLB (0.37) | MAPTCYP3A4TSHRALDH1A1MEN1 | |
| SCHEMBL6903843 | 0.85 | POLB (0.36) | MAPTCYP3A4TSHRALDH1A1POLB | |
| SCHEMBL11453583 | 0.83 | HTT (0.41) | HTTMAPTCYP3A4TSHRALDH1A1 | |
| SCHEMBL19746578 | 0.82 | HTT (0.44) | HTTMAPTCYP3A4TSHRALDH1A1 | |
| SCHEMBL8970777 | 0.82 | MAPT (0.43) | HTTMAPTCYP3A4TSHRALDH1A1 | |
| SCHEMBL9545947 | 0.78 | POLB (0.36) | MAPTTSHRMEN1KMT2AKDM4E | |
| SCHEMBL9487252 | 0.77 | TSHR (0.35) | HTTMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL10337980 | 0.74 | TSHR (0.34) | CYP3A4TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL9466795 | 0.74 | CHRNA7 (0.34) | MAPTTSHRALDH1A1POLBATM | |
| SCHEMBL404531 | 0.74 | ANPEP (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667959-A1 | BIPHENYLOXY-ACIDS | Wyeth (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030702-A1 | BIPHENYLOXY-ACIDS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |