Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009406 | 0.83 | KDM4E (0.60) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL8298676 | 0.83 | KDM4E (0.47) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL11325544 | 0.79 | KDM4E (0.50) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL7933092 | 0.79 | KDM4E (0.56) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL18029143 | 0.79 | GPR17 (0.46) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL3342092 | 0.77 | CYP1A2 (0.49) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL596865 | 0.76 | CYP3A4 (0.56) | KDM4EMAPTALDH1A1GPR17POLB | |
| SCHEMBL3566658 | 0.74 | AKR1C2 (0.53) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL29612371 | 0.74 | KDM4E (1.00) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL379103 | 0.74 | KDM4E (1.00) | KDM4EMAPTGAAALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101759628-B | Ethynylindole compounds | ONO PHARMACEUTICAL CO | 2013-02-27 | — | — | CN | disclosed |
| US-8115014-B2 | Ethynylindole compounds | ONO Pharmaceuticals, Co., Ltd. (JP) | 2012-02-14 | — | — | US | disclosed |
| EP-2206698-A1 | Ethynylindole compounds | ONO Pharmaceutical Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
| US-20100160647-A1 | ETHYNYLINDOLE COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160647-A1 | ETHYNYLINDOLE COMPOUNDS | CYSLTR2, CYSLTR1, LTB4R2 | KDM4E 4771/4885MAPT 4109/4885GAA 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.