Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989569 | 1.00 | LMNA (0.45) | LMNAMAPTCCNCCDK8HDAC8 | |
| SCHEMBL3688515 | 0.82 | CA12 (0.55) | LMNANPC1RAB9ACA12CA7 | |
| SCHEMBL3688513 | 0.82 | CA12 (0.55) | LMNANPC1RAB9ACA12CA7 | |
| SCHEMBL29550737 | 0.81 | DPP4 (0.48) | LMNAMAPTCCNCCDK8NPC1 | |
| SCHEMBL20439711 | 0.81 | DPP4 (0.48) | LMNAMAPTCCNCCDK8NPC1 | |
| SCHEMBL1549366 | 0.81 | MEN1 (0.56) | LMNAHDAC8MEN1HSP90AA1KMT2A | |
| SCHEMBL1549368 | 0.81 | MEN1 (0.56) | LMNAHDAC8MEN1HSP90AA1KMT2A | |
| SCHEMBL17032627 | 0.80 | GABRA5 (0.47) | LMNAMAPTNPC1RAB9AFFAR1 | |
| SCHEMBL16319027 | 0.79 | MEN1 (0.53) | LMNAHDAC8NPC1RAB9AMEN1 | |
| SCHEMBL16319026 | 0.79 | MEN1 (0.53) | LMNAHDAC8NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |