Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5991530 | 0.90 | KMT2A (0.44) | IDO1KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL27577985 | 0.89 | IDO1 (0.39) | IDO1KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL5989816 | 0.84 | IDO1 (0.45) | IDO1KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL5989793 | 0.84 | IDO1 (0.46) | IDO1KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL5989703 | 0.82 | IDO1 (0.50) | IDO1KMT2AMEN1TDP1MAPT | |
| Hydroxyamine SCHEMBL6139363 | 0.82 | IDO1 (0.44) | IDO1KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL14590721 | 0.81 | MAP2K1 (0.49) | IDO1KMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL5989631 | 0.81 | MEN1 (0.61) | KMT2AMEN1CYP1A2CYP2C19TDP1 | |
| SCHEMBL14590725 | 0.81 | MAP2K1 (0.48) | IDO1KMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL14590718 | 0.79 | MAP2K1 (0.46) | IDO1KMT2AMEN1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030119-B1 | Method for treating chronic pain using MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1144385-B1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-08-17 | — | — | EP | disclosed |
| CN-1177830-C | Benzoheterocycles and their use as MEK inhibitors | ��ʲ | 2004-12-01 | — | — | CN | disclosed |
| US-6469004-B1 | Benzoheterocycles and their uses as MEK inhibitors | WARNER-LAMBERT COMPANY | 2002-10-22 | — | — | US | disclosed |
| CN-1358094-A | Methods of treating chronic pain with MEK inhibitors | WARNER LAMBERT CO (US) | 2002-07-10 | — | — | CN | disclosed |
| EP-1202731-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| CN-1333754-A | Benzoheterocycles and their use as MEK inhibitors | WARNER LAMBERT CO (US) | 2002-01-30 | — | — | CN | disclosed |
| EP-1144385-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005390-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000042022-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |