Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.55 |
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130100 | 0.89 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1BCL2MCL1MAPT | |
| SCHEMBL28424851 | 0.85 | BCL2 (0.59) | BCL2MCL1LMNAMAPTHPGD | |
| SCHEMBL10138484 | 0.84 | ALDH1A1 (0.50) | HSP90AA1HSP90AB1BCL2MCL1LMNA | |
| SCHEMBL1649282 | 0.80 | ALDH1A1 (0.62) | HSP90AA1HSP90AB1MCL1HPGDKDM4E | |
| SCHEMBL28355059 | 0.80 | BCL2 (0.58) | BCL2MCL1LMNAMAPTHPGD | |
| SCHEMBL5992775 | 0.80 | MAPT (0.55) | BCL2MCL1LMNAMAPTHPGD | |
| SCHEMBL11858542 | 0.79 | LIG1 (0.65) | HSP90AA1HSP90AB1BCL2MCL1LMNA | |
| SCHEMBL29823118 | 0.77 | CSNK2A1 (0.63) | LMNAMAPTHPGDKDM4ECYP3A4 | |
| SCHEMBL147250 | 0.77 | CSNK2A1 (0.63) | LMNAMAPTHPGDKDM4ECYP3A4 | |
| SCHEMBL30718463 | 0.77 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |