Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexelvucitabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | POLG | P54098 | 1/20 | 0.39 |
| ▸ | DCK | P27707 | 7/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elvucitabine SCHEMBL3298257 | 1.00 | ALB (0.55) | ALBLMNAALDH1A1BLMPOLB | |
| Elvucitabine SCHEMBL1649928 | 1.00 | ALB (0.55) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL13770316 | 0.88 | ALB (0.47) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL13594946 | 0.87 | ALB (0.46) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL4749034 | 0.84 | LMNA (0.59) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL5952944 | 0.84 | LMNA (0.59) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL30667453 | 0.84 | LMNA (0.46) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL12149532 | 0.84 | ALB (0.44) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL1738785 | 0.82 | ALB (0.43) | ALBLMNAALDH1A1BLMPOLB | |
| SCHEMBL4288548 | 0.82 | LMNA (0.44) | ALBLMNAALDH1A1BLMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6383 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144879-A1 | ANTI-VIRAL AND HEPATIC-TARGETED DRUGS | AI-BIOPHARMA (FR) | 2026-05-28 | — | — | US | claimed |
| CN-224278664-U | Rail type conveyor with protection structure | Jinan Haihe Port Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-115522698-B | Assembled steel structure stair and assembling method thereof | HARBIN ENGINEERING UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122083595-A | Small-sized fruit and vegetable low-temperature instant freezer and control method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-224277835-U | Automatic cleaning and packaging device for plastic suction tray | Wuhu jinmingli logistics equipment Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-224285734-U | Brace rod rib alignment measuring tool | LIU XIAODONG (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-224275249-U | Carbon fiber plate processing equipment | Jilin Guoxing Carbon Fiber Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-224259797-U | Magnetic attraction type quick-mounting antistatic PVC coiled material | 武汉砚笛实业有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-224255934-U | Combined injection mold | 无锡申博机械制造有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-121132164-B | Semi-automatic pipe fitting alignment welding device and welding method | 山东金利智能科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-20070264241-A1 | Compounds for Enhanced Cancer Therapy | ZGENE A/S (DK) | 2007-11-15 | — | — | US | claimed |
| WO-2007106450-A2 | DIKETO ACIDS WITH NUCLEOBASE SCAFFOLDS: ANTI-HIV REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE IN COMBINATION THERAPY | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2007-09-20 | — | — | WO | claimed |
| US-7205404-B1 | Phosphorus-containing prodrugs | METABASIS THERAPEUTICS, INC. (US) | 2007-04-17 | — | — | US | claimed |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | EMORY UNIVERSITY | 2004-08-26 | — | — | US | claimed |
| EP-1361227-A2 | [5-carboxamide or 5-fluoro]-[2', 3'-unsaturated or 3'-modifield]-pyrimidine nucleosides | Emory University (US) | 2003-11-12 | — | — | EP | claimed |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | EMORY UNIVERSITY | 2002-12-26 | — | — | US | claimed |
| US-6194391-B1 | CS-87 (TITLE COMPOUND) INDUCES A TRANSIENT MUTATION IN HIV-1 AT THE 70TH CODON OF THE REVERSE TRANSCRIPTASE REGION OF THE VIRUS; ADMINISTERING TO A HUMAN IN NEED OF THERAPY WITH A DRUG THAT INDUCES A MUTATION IN HIV-1 AT ANOTHER LOCATION | EMORY UNIVERSITY | 2001-02-27 | — | — | US | claimed |
| EP-0805683-A4 | 5-CARBOXAMIDO OR 5-FLUORO]- 2',3'-UNSATURATED OR 3'-MODIFIED]-PYRIMIDINE NUCLEOSIDES | UNIV EMORY (US) | 1999-09-01 | — | — | EP | claimed |
| EP-0805683-A1 | 5-CARBOXAMIDO OR 5-FLUORO]- 2',3'-UNSATURATED OR 3'-MODIFIED]-PYRIMIDINE NUCLEOSIDES | EMORY UNIVERSITY (US) | 1997-11-12 | — | — | EP | claimed |
| WO-1996022778-A1 | DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR | EMORY UNIVERSITY (US) | 1996-08-01 | — | — | WO | claimed |