Elvucitabine

Elvucitabine

SCHEMBL1649928

Nc1nc(=O)n([C@@H]2C=C[C@H](CO)O2)cc1F

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

Ppol

The experimentally established mechanism targets of Elvucitabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALB P02768 4/20 0.55
LMNA P02545 6/20 0.46
ALDH1A1 P00352 2/20 0.46
BLM P54132 2/20 0.46
POLB P06746 1/20 0.46
ADRA1A P35348 1/20 0.46
POLG P54098 1/20 0.39
DCK P27707 7/20 0.35
PDE3A Q14432 3/20 0.34
PDE4D Q08499 1/20 0.34
SLC29A1 Q99808 1/20 0.34
MTOR P42345 2/20 0.34
DNMT1 P26358 2/20 0.34
THRB P10828 1/20 0.34
MDM2 Q00987 1/20 0.34
NCOA1 Q15788 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
GMNN O75496 1/20 0.34
TP53 P04637 1/20 0.34
NFKB1 P19838 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Elvucitabine SCHEMBL3298257 1.00 ALB (0.55) ALBLMNAALDH1A1BLMPOLB
Dexelvucitabine SCHEMBL599014 1.00 ALB (0.55) ALBLMNAALDH1A1BLMPOLB
SCHEMBL13770316 0.88 ALB (0.47) ALBLMNAALDH1A1BLMPOLB
SCHEMBL13594946 0.87 ALB (0.46) ALBLMNAALDH1A1BLMPOLB
SCHEMBL4749034 0.84 LMNA (0.59) ALBLMNAALDH1A1BLMPOLB
SCHEMBL5952944 0.84 LMNA (0.59) ALBLMNAALDH1A1BLMPOLB
SCHEMBL30667453 0.84 LMNA (0.46) ALBLMNAALDH1A1BLMPOLB
SCHEMBL12149532 0.84 ALB (0.44) ALBLMNAALDH1A1BLMPOLB
SCHEMBL1738785 0.82 ALB (0.43) ALBLMNAALDH1A1BLMPOLB
SCHEMBL4288548 0.82 LMNA (0.44) ALBLMNAALDH1A1BLMPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1402 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-12611453-B2 Method of inducing an HIV-1-specific immune response using a chimpanzee adenovirus vector encoding an hivacat t-cell immunogen and TLR7 agonist GILEAD SCIENCES, INC. (US) 2026-04-28 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
EP-3790536-B1 NANOCONTAINERS FOR TRANSPORTING NONPOLAR, LIPOPHILIC SUBSTANCES SUCH AS ANTIBIOTICS KARLSRUHER INST TECHNOLOGIE (DE) 2026-04-22 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
EP-3914604-B1 COMPOSITIONS COMPRISING CENSAVUDINE OR ELVUCITABINE FOR TREATING AGE-ASSOCIATED INFLAMMATION AND DISORDERS UNIV BROWN (US) 2026-03-04 EP claimed
US-20260021101-A1 COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDERS BROWN UNIVERSITY (US) 2026-01-22 US claimed
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2025-11-06 US claimed
EP-4642484-A1 TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 EP claimed
US-8703801-B2 Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2014-04-22 US claimed
US-20120282218-A1 PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. (US) 2012-11-08 US claimed
EP-2509949-A2 PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS University Of Georgia Research Foundation, Inc. (US) 2012-10-17 EP claimed
WO-2011071849-A2 PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2011-06-16 WO claimed
US-20100092427-A1 Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) 2010-04-15 US claimed
EP-2046328-A2 PYRIDINONE DIKETO ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2009-04-15 EP claimed
WO-2008010953-A2 PYRIDINONE DIKETO ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2008-01-24 WO claimed
US-20070264241-A1 Compounds for Enhanced Cancer Therapy ZGENE A/S (DK) 2007-11-15 US claimed
WO-2007106450-A2 DIKETO ACIDS WITH NUCLEOBASE SCAFFOLDS: ANTI-HIV REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE IN COMBINATION THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2007-09-20 WO claimed
US-7205404-B1 Phosphorus-containing prodrugs METABASIS THERAPEUTICS, INC. (US) 2007-04-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES FCGR2A, FCGR3B, FCGR1A ALB 302/4885LMNA 4284/4885ALDH1A1 1399/4885
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 ALB 3481/4885LMNA 1661/4885ALDH1A1 2758/4885
US-12611453-B2 Method of inducing an HIV-1-specific immune response using a chimpanzee adenovirus vector encoding an hivacat t-cell immunogen and TLR7 agonist IRF3, STING1, MAVS ALB 4430/4885LMNA 1350/4885ALDH1A1 3466/4885
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule CD4, TAP1, MCTS1 ALB 521/4885LMNA 2109/4885ALDH1A1 4592/4885
US-20100092427-A1 Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy TKT, DHFR, DTYMK ALB 4476/4885LMNA 3285/4885ALDH1A1 1645/4885
US-20120282218-A1 PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS PAICS, DUT, AADAC ALB 4691/4885LMNA 3895/4885ALDH1A1 2717/4885
US-20070264241-A1 Compounds for Enhanced Cancer Therapy TYMP, BAD, NUDT1 ALB 4112/4885LMNA 1899/4885ALDH1A1 1106/4885
US-20260021101-A1 COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDERS TPMT, HPRT1, APRT ALB 3859/4885LMNA 1066/4885ALDH1A1 1900/4885
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS DCLRE1A, CCR3, CCR8 ALB 1902/4885LMNA 852/4885ALDH1A1 2641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.