Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990255 | 1.00 | KMT2A (0.46) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL11117549 | 0.85 | KMT2A (0.43) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL11117546 | 0.85 | KMT2A (0.43) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL11117551 | 0.83 | TSHR (0.44) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL10657583 | 0.82 | KMT2A (0.52) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL10657588 | 0.82 | KMT2A (0.52) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL10661540 | 0.82 | NPC1 (0.46) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL10660889 | 0.81 | NPC1 (0.45) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL10660892 | 0.81 | NPC1 (0.45) | KMT2ALMNAGAANPC1SMN1; SMN2 | |
| SCHEMBL5990108 | 0.80 | NPC1 (0.53) | KMT2ALMNAGAANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |