Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | CA7 | P43166 | 5/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006480 | 0.88 | CA12 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1463530 | 0.80 | PIN1 (0.44) | TP53CYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL3344926 | 0.78 | CA12 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3347843 | 0.77 | TP53 (0.40) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1464398 | 0.75 | TSHR (0.48) | TP53CYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL10171688 | 0.75 | POLB (0.44) | TP53SMN1; SMN2TDP1ALDH1A1MEN1 | |
| SCHEMBL11066678 | 0.73 | ESR2 (0.38) | TP53ESR1ESR2SMN1; SMN2CYP3A4 | |
| SCHEMBL3687042 | 0.73 | ALDH1A1 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9694900 | 0.72 | ESR2 (0.37) | ESR1ESR2SMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL11736394 | 0.72 | HPN (0.54) | CA1CA2TP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |